Nonprofessional phagocytosis in trophectoderm cells of human preimplantation blastocysts
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چکیده
منابع مشابه
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متن کاملWNT3 and membrane-associated β-catenin regulate trophectoderm lineage differentiation in human blastocysts.
WNT/β-catenin signaling has been described as a crucial regulator of embryonic stem cells and embryogenesis. However, little is known on its role during human preimplantation embryo development, besides the RNA expression of its multiple players. In this study, we performed β-catenin loss- and gain-of-function studies on human preimplantation embryos by adding either Cardamonin or GSK3 inhibito...
متن کاملHuman trophectoderm cells are not yet committed.
STUDY QUESTION Are human trophectoderm (TE) cells committed or still able to develop into inner cell mass (ICM) cells? SUMMARY ANSWER Human full blastocyst TE cells still have the capacity to develop into ICM cells expressing the pluripotency marker NANOG, thus they are not yet committed. WHAT IS KNOWN ALREADY Human Day 5 full blastocyst TE cells express the pluripotency markers POU5F1, SOX...
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BACKGROUND Recent advancement in both human embryology and preimplantation genetic screening has created a completely new situation for human assisted reproduction. Embryos, typically at blastocyst stage, are biopsied and screened by DNA microarray or next-generation sequencing before cryopreservation, and then euploid embryos are warmed for transfer. Increased embryo implantation rates have be...
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ژورنال
عنوان ژورنال: Systems Biology in Reproductive Medicine
سال: 2016
ISSN: 1939-6368,1939-6376
DOI: 10.1080/19396368.2016.1183719